タンパク質キナーゼCの過剰活性により,前頭前皮質の働き記憶の調節が損なわれます

S G Birnbaum¹, P X Yuan, M Wang

¹Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06520-8001, USA.

Science (New York, N.Y.)

|October 30, 2004

まとめ

前頭前皮質における高タンパク質キナーゼC (PKC) 活動が,作業記憶を損なう. これは,過剰なPKC活性化が認知機能を妨害し,潜在的に注意散漫性や衝動性などの問題を引き起こすことを示唆しています.

科学分野:

神経科学は神経科学である.
コグニティブ・サイエンスコグニティブ・サイエンス
バイオケミストリーバイオケミストリー

背景:

前頭前皮質 (PFC) は,ワーキングメモリを含むより高い認知機能に不可欠です.
作業記憶には,思考,行動,感情を調節するための表現的知識が含まれています.
タンパク質キナーゼC (PKC) は,神経機能に関与する細胞内信号伝達経路である.

研究の目的:

前頭前皮質 (PFC) の認知機能に対する細胞内タンパク質キナーゼC (PKC) 信号伝達の影響を調査する.
PKCのアクティビティレベルが作業記憶のパフォーマンスにどのように影響するか判断する.

主な方法:

作業記憶の行動的評価について.
前頭前皮質における電気生理学的記録.
PKCの活動レベルを操作する.

主要な成果:

PFCにおけるPKCの活性が上昇すると,作業記憶の行動測定値が著しく低下する.
電気生理学的データは,行動的発見を裏付け,PFC機能の障害を示した.
PKCの活性を増やすことが知られているストレスへの曝露は,作業記憶の障害と関連していました.

結論:

前頭前皮質における過度のPKC活性化は,作業記憶と認知の調節を妨げます.
この障害は,PFC機能不全の症状の根底にある可能性があります,例えば,注意散漫性,判断力低下,衝動性,思考障害などです.
PKCシグナリングをターゲットにすることで,認知障害に対する治療戦略を提供することができる.

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