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Updated: Aug 8, 2026

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
13:15

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

Published on: February 25, 2016

Cdk2独立のS相エントリーには,サイクリンEにおけるセンターソーマル局所化信号が必要である

Yutaka Matsumoto1, James L Maller

  • 1Howard Hughes Medical Institute (HHMI) and Department of Pharmacology, University of Colorado School of Medicine, Denver, CO 80262, USA.

Science (New York, N.Y.)
|October 30, 2004
PubMed
まとめ

サイクリンEの新たに特定されたセンターソーマル局所化信号 (CLS) は,DNA合成と細胞サイクル進行に不可欠です. このシグナルにより,サイクリンEはCdk2とは独立してS相へのエントリーを促進し,がん細胞の増殖に関する新しい洞察を提供することができます.

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