肥満と関連した左心室動脈の特徴の変化
Chiew Y Wong1, Trisha O'Moore-Sullivan, Rodel Leano
1University of Queensland, Brisbane, Australia.
Circulation
|November 3, 2004
まとめ
肥満は,診断された心臓病がない場合でも,サブクリニカルな心臓病の変化と関連しています. 体重指数 (BMI) の上昇は,左心室 (LV) の機能の低下と,肥満および肥満患者の心筋反射率の増加と相関する.
科学分野:
- 心臓病学 心臓病学
- 肥満医学 肥満医学とは
- メディカルイマージング (医学イメージング)
背景:
- 肥満は,心不全の既知の危険因子である.
- 心臓の構造と機能に対する体重の独立した影響は,併発性疾患とは別に,さらなる調査を必要としています.
- 体重指数 (BMI) とインスリン濃度に関連したサブクリニック性心筋動脈障害は十分に確立されていません.
研究 の 目的:
- 体質指数 (BMI) とインスリン濃度との関連を研究し,亜臨床性心筋疾患との関連を調査する.
- 体重過多と肥満が,心臓の構造と機能の変化と関連しているかどうかを,他の健康状態から独立して判断する.
主な方法:
- 心筋ドープラー検査 (シストリック[sm]と初期ダイアストリック速度[em]),ストレイン,ストレインレート画像,組織特徴化 (統合バックスケーター [CVIB]のサイクル変化,整合バックスケーター [cIB]の校正) を含む心房エコー.
- 研究には109人の超重または肥満の被験者と33人の参照者 (BMI <25 kg/m2) が含まれていました.
- 分析は,平均動脈圧,年齢,性別,左心室 (LV) 質量により調整された.
主要な成果:
- 高いBMIは,増加したLV質量と壁の厚さと相関していた.
- 重度の肥満 (BMI >35) の被験者は,レファレンスと比較して,LVのシストリックおよびダイアストリック機能の低下と心筋反射率の増加を示した.
- 肥満や軽度肥満の個人は,同様の,しかしより顕著ではない,機能的および反射性の変化を示した;これらは,断食インスリンレベルと運動能力の低下と相関した.
結論:
- 明らかな心疾患のない肥満の個人は,左心室 (LV) の構造と機能の亜臨床的変化を示しています.
- これらの変化は,平均動脈圧,年齢,性別,およびLV質量などの要因とは無関係に発生します.
- 研究結果は,高BMIが心臓病の臨床的表れになる前に,心筋動脈障害に寄与することを示唆しています.
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