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Updated: Jun 20, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

Published on: August 21, 2016

骨粗鬆症のアウトカムにESR1遺伝子ポリモルフィズムによる異なる遺伝的影響

John P A Ioannidis1, Stuart H Ralston, Simon T Bennett

  • 1Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece. jioannid@cc.uoi.gr

JAMA
|November 4, 2004
PubMed
まとめ

エストロゲン受容体アルファ (ESR1) 遺伝子は骨折リスクに影響するが,骨密度に影響しない. 特定のESR1変種であるXbaIは,骨のミネラル密度から独立したメカニズムを通じて,女性における骨折リスクを大幅に低減します.

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