抗生物質または手術は,小児におけるベシコウレテリック・リフリュークスの治療です
Vassilios Fanos1, Luigi Cataldi
1Neonatal Intensive Care Unit, University of Cagliari, 09124 Cagliari, Italy. vafanos@tiscali.it
Lancet (London, England)
|November 9, 2004
まとめ
子どもにおける膀逆流 (VESICOURETERIC REFLUX,VUR) 治療については,依然として議論が続いている. メタアナリシスは,VUR介入の不確実な利点と,抗生物質に対する手術のわずかな利点を発見しました.
科学分野:
- 小児腎臓病理学について
- 泌尿器科 泌尿器科とは
- 根拠に基づいた医学は,証拠に基づいた医療です.
背景:
- 膀逆流 (VESICOURETERIC REFLUX,VUR) は,子供の1~2%に罹患し,腎臓の損傷につながる可能性があります.
- 観察,抗生物質,手術を含むVURの治療オプションについて議論されています.
- 現在のガイドラインは,抗生物質にもかかわらず,進行性腎臓損傷による再発性尿路感染症の手術を推奨しています.
研究 の 目的:
- 治療なしと比較してVUR介入の利点を評価する.
- 抗生物質の予防に比べて外科手術の追加的利点を評価する.
- VUR管理の将来の戦略を探求する.
主な方法:
- 10件のランダム化対照試験のメタ解析.
- VURを患った964人の子どもも含まれていた.
- 尿路感染症の発生率,腎損傷,腎機能などの評価されたエンドポイント.
主要な成果:
- VURを特定し,治療する臨床的利点については,不確実性があります.
- 抗生物質に対する外科介入の付加利益は最小限です.
- ルーティン・シストウレトログラフィーのような現在の慣行は,再評価を必要とします.
結論:
- 新しいVUR管理戦略は,より適合した,より侵襲的でないアプローチに焦点を当てるべきです.
- 将来の目標は,尿路動脈異常の矯正よりも腎臓パレンキマ損傷の予防を重視しています.
- VURのプレゼンテーションに基づいて,男の子と女の子の異なる管理は,おそらく必要である.
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