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Updated: Jul 14, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

穴を作る変異に対するタンパク質構造の反応と,水害性効果との関連

A E Eriksson1, W A Baase, X J Zhang

  • 1Institute of Molecular Biology, Howard Hughes Medical Institute, Eugene, OR.

Science (New York, N.Y.)
|January 10, 1992
PubMed
まとめ

T4ライソ酵素にヒドロホビック残留物を変異させることで穴を開けることで,タンパク質の安定性が低下した. この不安定化は空洞の大きさと相関しており,タンパク質における水害性効果の洞察を提供している.

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