メタクリロンニトリルのニッケル (((II)) 触媒による高度なエナチオセレクティブの水リン酸化である
Aaron D Sadow1, Isabelle Haller, Luca Fadini
1Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Hönggerberg, CH-8093 Zürich, Switzerland.
Journal of the American Chemical Society
|November 13, 2004
まとめ
新しいニッケル複合体は,メタクリロニトリルにフォスフィンの添加を触媒化し,高い効率とエナチオセレクティブ性を達成します. このヒドロフォスフィネーション反応は,貴重な化学化合物を合成するための新しい経路を提供します.
科学分野:
- 有機金属化学 有機金属化学
- カタリシス カタリシス カタリシス
- オーガニック・シンセシス オーガニック・シンセシス
背景:
- ハイドロフォスフィネーション反応は,炭素-リン結合の形成に不可欠です.
- 効率的でエナチオセレクティブな触媒システムの開発は,依然として大きな課題です.
研究 の 目的:
- フェロセニルホスフィンのリガンドを併用したダイケーション性Ni (II) 複合体の触媒活性を調べる.
- 大量の二次フォスフィンを用いてメタクリロンチリルのエナンチオセレクティブ水素フォスフィネーションを調査する.
主な方法:
- [Ni ((ピピフォス)) ((THF)) ] ((ClO4) 2複合体の合成と特徴付け.
- メタクリロニトリルの水リン酸化におけるニッケル複合体の触媒試験.
- 主要な反応中間物質の分離と構造分析.
主要な成果:
- ニッケル複合体は,ターンオーバー数 (TON) が900までで,効率的に水酸化反応を触媒化する.
- 94%に達する高いエナンチオセレクティビティが達成されました.
- 触媒的に活性なN-コーディネートメタクリロニトリルニッケル複合体の中間物質が分離され,特徴づけられ,提案された触媒サイクルをサポートしました.
結論:
- ディカチオンのNi (II) 複合体は,エナチオセレクティブヒドロフォスフィネーションの非常に効果的な触媒である.
- この研究は,1,4-結合添加を含む触媒サイクルを明らかにした.
- この研究は,エナチオメリックに濃縮された有機リン化合物を合成するための貴重な方法を提供します.
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