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TROSPAは,Borrelia burgdorferiに対するIxodes scapularisの受容体である

Utpal Pal¹, Xin Li, Tian Wang

¹Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

|November 13, 2004

まとめ

研究者らは,Borrelia burgdorferiのコロニー化に不可欠な受容体,TROSPAを発見しました. TROSPAをブロックすると,ライム病のバクテリアがダニに感染するのを防ぎ,哺乳類への感染を軽減します.

科学分野:

微生物学微生物学とは
ベクター生物学ベクター生物学
寄生虫学とは,寄生虫学である.

背景:

ライム病は,と哺乳類の間を循環するバクテリアであるBorrelia burgdorferiによって引き起こされます.
病原体-ベクター相互作用を理解することは,病気の伝播を制御する鍵です.

研究の目的:

ボレリア・ブルグドーフェリ (Borrelia burgdorferi) が Ixodes scapularis のコロニー化に関与するティックの受容体を特定する.
ライム病の伝染サイクルにおけるTROSPAの役割を調査する.

主な方法:

生物化学的測定を用いて,受容体TROSPAを特定した.
Borrelia burgdorferiの感染後に分析されたTROSPA mRNAレベル.
抗血清とRNA干渉を用いてTROSPAの機能を阻害する in vivo.

主要な成果:

Borrelia burgdorferiの外表面タンパク質Aは,受容体TROSPA.に直接結合する.
TROSPA発現レベルは,のBorrelia burgdorferi存在と相関しています.
TROSPAを阻害すると,細菌の結合とベクトルコロニー化を著しく減少させました.

結論:

TROSPAは,Borrelia burgdorferiとIxodes scapularisのコロニー化に欠かせないものです.
TROSPAをターゲットにすることは,ライム病の伝播を妨害する潜在的な戦略です.

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