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Updated: Jul 13, 2026

Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases
09:54

Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases

Published on: December 26, 2011

NKT細胞によるリゾソーム性グリコスフィンゴリピドの認識

Dapeng Zhou1, Jochen Mattner, Carlos Cantu

  • 1University of Chicago, Department of Pathology, Chicago, IL 60637, USA. dzhou@midway.uchicago.edu

Science (New York, N.Y.)
|November 13, 2004
PubMed
まとめ

研究者らは,イソグローボトリヘクソシルセラミド (iGb3) を,自然殺傷性T細胞 (NKT) の内生リガンドとして特定した. この脂質はNKT細胞の発達に不可欠であり,感染症,がん,自己免疫における免疫反応を調節する可能性があります.

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Overview
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Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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Delivery Pathways to the Lysosome

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Endocytosis
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Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Cells of the Innate Immune Response

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Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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