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Updated: Dec 31, 2025

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay
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エストロゲン受容体ベータ選択リガンドの構造ベースの設計

Eric S Manas1, Rayomand J Unwalla, Zhang B Xu

  • 1Department of Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA. manase@wyeth.com

Journal of the American Chemical Society
|November 19, 2004
PubMed
まとめ

構造ベースの設計を使用して,エストロゲン受容体ベータ (ERbeta) 選択リガンドを最適化しました. 微妙な結合ポケットの差異は100倍以上のERbeta選択性を生み出し,選択的なエストロゲン受容体調節器の開発を進めました.

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