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Updated: May 5, 2026

Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices
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Published on: March 15, 2018

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デンドリット統合の行動的役割:HCN1チャネルは,CA1ピラミッドニューロンの遠端デンドリットへの入力で空間記憶と可塑性を制限する

Matthew F Nolan1, Gaël Malleret, Josh T Dudman

  • 1Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

Cell
|November 20, 2004
PubMed
まとめ

マウスのHCN1遺伝子を削除すると,ヒポカンプスのシナプス可塑性を改善することによって,学習と記憶を向上させます. これは,HCN1チャネルが通常, dendritic 統合を調節することによって,認知機能を制限することを示唆しています.

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