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Updated: May 13, 2026

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases
06:10

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases

Published on: December 23, 2013

人間の5' --> 3'外核酵素Xrn2は,共転写分裂部位での転写終了を促進する

Steven West1, Natalia Gromak, Nick J Proudfoot

  • 1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Nature
|November 27, 2004
PubMed
まとめ

この研究では,ポリ (A) シグナルで作用する共転写分裂 (CoTC) 活動が,Xrn2外核酵素によるRNAの分解を開始することを明らかにしました. このプロセスは,RNAポリメラーゼII (Pol II) の解離と転写終結につながり,魚雷モデルを支持します.

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