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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.1K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Overview of Cell Signaling01:23

Overview of Cell Signaling

23.6K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
23.6K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

5.8K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
5.8K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

9.5K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
9.5K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

7.5K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
7.5K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

52.4K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
52.4K

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関連する実験動画

Updated: Dec 17, 2025

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
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Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

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エチレンシグナル伝達経路は,

Jose M Alonso1, Anna N Stepanova

  • 1Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA. jmalonso@unity.ncsu.edu

Science (New York, N.Y.)
|November 30, 2004
PubMed
まとめ
この要約は機械生成です。

植物は,成長とストレス反応を調節するために,単純な炭化水素ガスのエチレンを使用します. 研究は,フォスフォトランスファー,EIN2,タンパク質の分解,および転写カスケードを含む複雑なシグナル伝達経路を明らかにしています.

さらに関連する動画

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
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Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

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Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay
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Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay

Published on: March 3, 2011

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関連する実験動画

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Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

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Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
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Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay
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科学分野:

  • 植物生物学 植物生物学
  • 分子シグナル伝達です.
  • バイオケミストリー バイオケミストリー

背景:

  • エチレンは,植物における重要なガスホルモンである.
  • それは様々な発達過程とストレス反応を調節する.
  • そのシグナル伝達メカニズムを理解することは不可欠です.

研究 の 目的:

  • 植物における複雑なエチレンシグナル伝達経路を解明するため.
  • 重要な分子成分とその相互作用を特定する.
  • 植物エチレンシグナリングの包括的な概要を提供する.

主な方法:

  • エチレンシグナリングに関する既存の研究のレビューと合成.
  • 古典的および新しいシグナル要素の分析.
  • アラビドプシス・サリアナの経路からのデータの統合.

主要な成果:

  • エチレンシグナル伝達における4つのコアモジュールの識別:フォスフォトランスファーリレー,EIN2ベースのユニット,ユビキチン媒介タンパク質分解,および転写カスケード.
  • これらのモジュール間の相互作用の解明.
  • カノニカルとアラビドプシスのエチレンシグナル伝達経路の詳細なマッピング.

結論:

  • エチレンシグナル伝達には,複数の相互作用するコンポーネントを持つ洗練された経路が含まれています.
  • 経路は,特定のプラントアウトプットを生成するために多様なインプットを統合します.
  • この研究は,植物ホルモンシグナル伝達に関する将来の研究のための基礎的な理解を提供します.