骨髄由来細胞から発生した胃がん

Jeanmarie Houghton¹, Calin Stoicov, Sachiyo Nomura

¹Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. jeanmarie.houghton@umassmed.edu

Science (New York, N.Y.)

|November 30, 2004

まとめ

ネズミの慢性ヘリコバクター感染症は,骨髄由来細胞 (BMDCs) が胃を再生させ,内皮がんを引き起こす可能性があります. これは,骨髄由来源からの上皮がん発達の新たな経路を示唆している.

科学分野:

腫瘍学腫瘍学
胃腸内科胃腸内科
幹細胞生物学幹細胞生物学

背景:

皮質がんは伝統的に組織幹細胞から発生すると考えられている.
骨髄由来細胞 (BMDCs) は,損傷と炎症の部位に浸透し,悪性腫瘍におけるその役割についての疑問を提起します.

研究の目的:

骨髄由来細胞 (BMDCs) が上皮がんの源として機能するかどうかを調査する.
慢性ヘリコバクター感染症がBMDCの採用と,その後の胃がんの発症における役割を調査する.

主な方法:

使用したC57BL/6マウスモデル.
誘発された慢性ヘリコバクター感染症は,知られた致癌物質です.
監視されたBMDCの募集,メタプラジア,および胃内膜の機能不全.

主要な成果:

急性損傷または炎症は,胃への重要なBMDC徴募を誘導しませんでした.
慢性ヘリコバクターの感染は,胃の実質的なBMDCの再定植につながりました.
採用されたBMDCは,メタプラジアとディスプラジアを経験し,内皮がんに進行した.

結論:

骨髄由来細胞 (BMDCs) は,特に慢性炎症の条件下で,上皮がんの源となる可能性があります.
この発見は,従来の幹細胞起源モデルに異議を唱え,多段階のがん進行に関する理解を広げています.

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