赤色フォトピグメントのポリモルフィズムは,色合いのバリエーションの背後にある
J Winderickx1, D T Lindsey, E Sanocki
1Department of Medicine, University of Washington, Seattle 98195.
Nature
|April 2, 1992
まとめ
人間の赤緑色の色覚には微妙な遺伝的変異がある. 赤色の視覚色素に共通する遺伝的ポリモルフィズムが,正常視力を持つ男性の2つの主要な色合いのグループを説明しています.
科学分野:
- 遺伝学 遺伝学とは
- 神経科学は神経科学である.
- ビジョン ビジョン 科学 科学
背景:
- 人間の感覚は遺伝的多様性を表しており,方法論的な制約のために研究することがしばしば困難である.
- 赤緑色の視覚は,赤と緑の視覚色素に依存し,X染色体遺伝子によってコードされます.
- 男性の正常な色覚は,色合いを合わせた2つの異なるグループを示し,遺伝的差異が根本にあることを示唆しています.
研究 の 目的:
- 赤緑色の色彩視の微妙な知覚の差異の遺伝的根拠を調査する.
- 正常な色彩視力を持つ男性の間で観察された色彩マッチングの違いに起因する特定の遺伝的変異を特定する.
主な方法:
- 洗練された技術を使用して,フォトピグメントのゲノタイプと心理物理的フェノタイプを評価しました.
- 赤と緑の視覚染色体アポタンパク質をコードするX関連遺伝子を分析した.
- 赤色視覚色素の残留180で一般的な単一アミノ酸多形態性を調査した.
主要な成果:
- 赤色の視覚的色素の残留180で一般的な単一アミノ酸多形態 (62% Ser,38% Ala) を特定しました.
- このポリモルフィズムは,正常な色覚を持つ男性の間で,色合いが一致する2つの主要なグループが存在することを説明します.
- 発見は,遺伝的差異による赤/緑の視覚色素のスペクトル位置づけの変動を示唆しています.
結論:
- 赤色視覚染色体遺伝子の一般的な多形態化は,正常な赤緑色色視力の変化に起因する.
- この遺伝的変異は,色合いの明確な知覚の違いにつながります.
- この研究は,人間の色彩視における既知の現象に対する分子的な説明を提供します.
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