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Updated: Jun 25, 2026

Study of Protein Dynamics via Neutron Spin Echo Spectroscopy
08:03

Study of Protein Dynamics via Neutron Spin Echo Spectroscopy

Published on: April 13, 2022

ヒューマン・ピュリン・ヌクレオシド・フォスフォリラーゼの振動を促進する. 分子ダイナミクスとハイブリッド量子力学/分子力学の研究である

Sara Núñez1, Dimitri Antoniou, Vern L Schramm

  • 1Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

Journal of the American Chemical Society
|December 2, 2004
PubMed
まとめ

ヒューマン・ピュリン・ヌクレオシド・フォスフォリラーゼ (hPNP) は,移行状態を安定させるために,タンパク質による振動を利用する. 酸素原子のこのダイナミックな圧縮は,電子密度を高め,ピューリン環の脱出グループ能力を改善することにより,酵素触媒を加速します.

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