ハイブリッドマイクロジェルは,近赤外線のスペクトル範囲で光反応する
Ivan Gorelikov1, Lora M Field, Eugenia Kumacheva
1Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M6S 3H6, Canada.
Journal of the American Chemical Society
|December 9, 2004
まとめ
私たちは,ポリマーマイクロゲルと金ナノロッドを使用して,新しい複合材料を開発しました. この材料は光に反応し,薬やタンパク質の制御された放出を可能にします.
科学分野:
- マテリアルサイエンス 材料科学
- ナノテクノロジー ナノテクノロジー
- ポリマー化学のポリマー化学について
背景:
- 制御物質の投与のためのスマート素材の開発は極めて重要です.
- 光熱効果は,材料反応のための非侵襲的なトリガーを提供します.
- ゴールドナノロッドは,近赤外線吸収のための調整可能な光学特性を示す.
研究 の 目的:
- 光熱に反応する複合材料を作るために.
- 光触発式アクチュエーションのための金ナノロッドでポリマーマイクロゲルを機能化します.
- 薬剤とタンパク質の配送におけるこの複合物の可能性を調査する.
主な方法:
- 近赤外線吸収のための特定の比率を持つ金ナノ棒を合成する.
- 金ナノ棒を温度に反応するポリ (N-イソプロピラクリラミド-アクリル酸) マイクロゲルに組み込む.
- ハイブリッドマイクロゲルを810nmレーザーで照射し,光熱効果を誘発する.
主要な成果:
- ゴールドナノロッドは,近赤外線"水窓"で強い吸収で成功裏に合成されました.
- 金ナノ棒でドーピングされたハイブリッドマイクロゲル粒子は,レーザー照射で顕著な脱水相移行を示した.
- 材料は制御された脱水を示し,ペイロードの解放の可能性を示した.
結論:
- ポリマーマイクロゲルと金ナノ棒を基にした新しい光熱反応性複合材料が成功裏に開発されました.
- 材料の光誘発による脱水行動は,金ナノロッドの光熱効果に起因する.
- この複合材料は,標的型薬剤および小分子配送システムにおけるアプリケーションの有望性を示しています.
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