鉛の累積暴露と男性における年齢関連の白内障のリスク
Debra A Schaumberg1, Flavia Mendes, Mini Balaram
1Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Mass 02215-1204, USA. dschaumberg@rics.bwh.harvard.edu
JAMA
|December 9, 2004
まとめ
累積的な鉛曝露は,高齢者の白内障の発症の重要な危険因子です. 環境における鉛の暴露を減らすことは,世界的に白内障の予防に役立つかもしれない.
科学分野:
- オフタルモロジック (眼科)
- 環境衛生 環境衛生 環境衛生
- ゲロントロジーはゲロントロジーの学科です.
背景:
- 低レベルの鉛曝露は,慢性的な年齢関連の疾患と関連しています.
- 白内障のレンズに鉛が含まれており,病原性における潜在的な役割を示唆しています.
- 鉛はレンズのリドックス状態とタンパク質構造を混乱させ,透明性を損なう可能性があります.
研究 の 目的:
- 累積的な鉛曝露と白内障の発症の関連性を調査する.
- 骨鉛濃度が白内障のリスクの増加と相関するかどうかを判断する.
主な方法:
- 骨の鉛濃度 (小腿骨および小腿骨) は,KX線光を用いて,ノルマティブエイジング研究から60歳以上の642人の男性で測定されました.
- 骨鉛測定後に白内障の発生について,眼科検査データをレビューした.
- ロジスティック回帰モデルは,白内障リスクの確率比 (ORs) と95%信頼区間 (CI) を計算するために使用されました.
主要な成果:
- の鉛濃度の最高クインティルの男性では,混同要因を調整した後に白内障のリスクが著しく高かった (OR=3.19).
- 軟骨の鉛濃度は,白内障のリスクの増加 (OR=1.88,P=.16) に関する非有意な傾向を示した.
- 短期間の被曝を示す血中鉛濃度は,白内障 (OR=0.89,P=.73) と有意に関連していなかった.
結論:
- 米国の成人の集団に共通する蓄積された鉛曝露は,白内障の重要な認識されていない危険因子です.
- 環境における鉛の曝露を減らすことで,世界的に白内障の発生率を低下させる可能性がある.
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