焦点性における心律乱症:将来的な長期的な研究
Fergus J Rugg-Gunn1, Robert J Simister, Mark Squirrell
1National Society for Epilepsy and Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK.
Lancet (London, England)
|December 22, 2004
まとめ
における突然の予期せぬ死は,アシストーラのような心律不整によって引き起こされる可能性があります. 継続的な心電図 (ECG) モニタリングにより,高リスクのエピレプシー患者における発作中の重大な心臓イベントが明らかになりました.
科学分野:
- 神経学 神経学とは
- 心臓病学 心臓病学
- エピレプシの研究研究
背景:
- を患っている患者は,潜在的に神経原性心律不整症による突然の予期せぬ死のリスクに直面します.
- 電気心臓図 (ECG) は心臓機能をモニタリングする方法を提供しており,埋め込みループレコーダーは最大18ヶ月間延長された監視を提供します.
研究 の 目的:
- 長期のモニタリング期間中,耐火性焦点発作を経験している患者の心臓発作の頻度を決定する.
主な方法:
- 植え付け可能なループレコーダーは,英国で耐火性焦点発作の20人の患者を監視するために使用されました.
- デバイスは,ブラジカルディア (時速40拍以下) または低心率 (時速140拍以上) を検出するようにプログラムされ,発作中に手動で心電図の記録を開始することができました.
- ECGデータを分析し,24ヶ月間にわたって患者の発作日記と相関させました.
主要な成果:
- 220,000時間以上の患者がモニタリングされ,377回の発作でECGを記録しました.
- 16人の患者では,通常の発作中に心拍数の中央値が1分100拍を超えました.
- イクタルブラジカルディアは,イベントの2.1% (7患者),ブラジカルディアまたはアシストーラを経験した患者の21%で発生し,潜在的に致命的なアシストーラを含む3人を含む4人の患者のペースメーカー挿入が必要になりました.
結論:
- エピレプシー患者における周期性心臓異常は,突然の予期せぬ死亡のリスクが最も高い患者との特徴を共有しています.
- アシストールは,多くのに関連した死亡の重要な要因であり,患者の調査と心臓ペース戦略に影響を与える可能性があります.
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