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Updated: Jul 16, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

水嫌ドメインに結合したヘムで再構成されたミオグロビンによる異常なリガンド差別

Hideaki Sato1, Masahiro Watanabe, Yoshio Hisaeda

  • 1Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka 812-8581, Japan.

Journal of the American Chemical Society
|January 6, 2005
PubMed
まとめ

化学的に改変されたミオグロビンは,一酸化炭素よりも酸素選択性を高めています. 水性ドメインの導入により,O2の結合と安定化が改善され,アミノ酸配列を変更することなく,リガンドの選択性が増加しました.

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