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ベータ・ラクタム系抗生物質は,グルタミン酸トランスポーター発現を増やすことで神経保護を提供します

Jeffrey D Rothstein1, Sarjubhai Patel, Melissa R Regan

  • 1Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA. jrothste@jhmi.edu

Nature
|January 7, 2005
PubMed
まとめ

セフトリアキソンなどのベータラクトーム抗生物質は,グルタミン酸トランスポーターGLT1 (EAAT2とも呼ばれる) の発現を刺激することができます. この神経保護効果は,グルタミン酸興奮毒性を含む神経学的疾患の治療に有望であることが示されています.

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