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Updated: Jul 12, 2026

A Modified Yeast-one Hybrid System for Heteromeric Protein Complex-DNA Interaction Studies
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リガンド設計と新しい二核銅複合体によって,DNA酸化選択性をデオキシリボースからグアニンに変化させる

Lei Li1, Kenneth D Karlin, Steven E Rokita

  • 1Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA.

Journal of the American Chemical Society
|January 13, 2005
PubMed
まとめ

新しい2核の銅複合体はDNA内のグアニンを選択的に酸化し,ユニークな誘導体を形成します. この銅複合体は,DNAの脊髄損傷に対する核塩基変異に対する高い選択性を示しています.

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