ヒトのマイクロRNA遺伝子の遺伝学的なシェーディングとコンピュータによる識別
Cell
|January 18, 2005
まとめ
研究者は,霊長類の種を分析することによって,ヒトゲノムに多数の新しいマイクロRNA (miRNA) を発見しました. この研究は,miRNA遺伝子の重要な保存パターンを明らかにし,将来の発見を支援します.
科学分野:
- ゲノミクスゲノミクスとは
- バイオインフォマティックス
- 分子生物学は分子生物学である.
背景:
- マイクロRNA (miRNA) は,遺伝子発現を調節する小さなノンコーディングRNAです.
- 種間のmiRNA遺伝子保存を理解することは,機能的要素の識別に不可欠です.
- 以前の推定では,ヒトのmiRNAsの完全なレパートリーを過小評価していた可能性がある.
関連する概念動画
MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...


