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Updated: May 2, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
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GSK-3βはCRMP-2のリン酸化とニューロンの極性を調節する

Takeshi Yoshimura1, Yoji Kawano, Nariko Arimura

  • 1Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan.

Cell
|January 18, 2005
PubMed
まとめ

グリコーゲン合成キナーゼ-3β (GSK-3β) は,リン酸化によりクララシン応答媒介タンパク質-2 (CRMP-2) を無効化し,アクソン形成を阻害する. ニューロトロフィン-3 (NT-3) はGSK-3βを無効化し,CRMP-2を活性化することによって軸索の成長を促します.

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