立方相と立方相分散は,フォスフォリピドベースのシステムで
Markus Johnsson1, Justas Barauskas, Fredrik Tiberg
1Camurus AB, Ideon, Gamma 2, Sölvegatan 41, SE-223 70, Lund, Sweden, and Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden. markus.johnsson@camurus.ideon.se
Journal of the American Chemical Society
|January 27, 2005
まとめ
本研究では,二オレオイルフォスファディテイルエタノアミン (DOPE) とペギラートグリセロールモノオレート (PEG660-GMO) を使用した立方体液晶相システムを特徴付けています. このシステムは,稀な条件下でも,安定した立方相構造を持つコロイド粒子を形成します.
科学分野:
- マテリアルサイエンス 材料科学
- バイオフィジックス 生物物理学
- 物理化学 物理化学
背景:
- フォスフォリピドベースの液晶相は,様々な用途において極めて重要です.
- ディオレオイルフォスファディテイルエタノアミン (DOPE) は,このようなフェーズを形成するための一般的なフォスホリピドです.
- これらの相,特にコロイド形式での安定化は,依然として課題です.
研究 の 目的:
- 新しい立方体液体結晶相系を特徴づけるために.
- DOPEベースの立方相に対するPEG化グリセロールモノオレート (PEG(660) -GMO) の効果を調査する.
- このシステムからコロイド粒子の形成を調査する.
主な方法:
- DOPE,PEG ((660)) -GMO,そして水を使ってシステムの準備.
- 異なる濃度における相行動分析.
- 立方相構造と粒子形成の特徴.
主要な成果:
- 安定した立方体液晶相がDOPE/PEG ((660) -GMO/水システムによって形成されました.
- 立方相は,相図の稀な領域で水と共存する.
- システムは,立方相構造を保持するコロイド粒子に分割することができます.
結論:
- PEG ((660) -GMOの添加は,DOPEベースの立方体液晶相を安定させます.
- このシステムは,安定した立方相ナノ粒子を作る方法を提供します.
- 薬剤投与および材料科学における潜在的な応用が示唆されています.
関連する概念動画
Two Components: Liquid–Liquid Systems
A pressure-composition phase diagram explicitly describes the behavior of an ideal solution of two volatile liquids under varying pressures and compositions. A pressure-composition diagram has two main curves. The bubble point curve represents the plot of pressure versus liquid mole fraction. It indicates the pressure at which the first bubble of vapor forms from the liquid phase as the system pressure decreases.The dew point curve is the pressure versus vapor mole fraction. It indicates the...
Nonideal Two-Component Liquid Solutions
Nonideal liquid solutions, also known as real solutions, do not strictly follow Raoult's law. Raoult's law is a rule of thumb in physical chemistry. However, not all mixtures adhere to this law due to varying molecular interactions. For example, in an acetone/chloroform solution, the individual vapor pressures of the components are lower than expected, resulting in a total vapor pressure below that predicted by Raoult's law, causing a negative deviation.On the other hand, in an ethanol/water...
Solid–Solid Solutions
The temperature-composition phase diagram of two solids, A and B, which are immiscible in the solid phase but form miscible liquids, shows that when the temperature is low, these two exist as separate, pure solids (A and B). As the temperature increases, they transition into a single-phase liquid solution where A and B coexist. Moving from point a1 to a2 in the phase diagram, the composition changes such that solid B begins to separate from the solution, enriching the remaining liquid with A.
Phase Diagrams of Ternary Systems
Consider a ternary system, which is composed of three components: water (W), ethanoic acid (E), and trichloromethane (T). Here, Ethanoic acid (E) is fully miscible with both water (W) and trichloromethane (T), meaning it can mix entirely with either of them. However, water and trichloromethane have partial miscibility, meaning they can only mix to a certain extent, beyond which two separate phases will form.The phase diagram of a ternary system is represented as an equilateral triangle, where...
Crystallographic Point Groups
Crystallographic point groups represent the various symmetry operations that can occur within crystals. They are unique in that at least one point will always remain unchanged during these actions. For instance, consider the triclinic system. This system, devoid of any axis or plane of symmetry, aligns with the C1 and Ci point groups.where Cᵢ is characterized solely by a center of inversion.Contrastingly, the monoclinic system introduces an element of symmetry. This system with one plane and...
Partial Fractions
A partial fraction is a component of a rational expression represented as the sum of simpler fractions. When a rational function is expressed as a ratio of two polynomials, it can often be decomposed into a sum of fractions whose denominators are simpler polynomials, typically linear or irreducible quadratic factors. This process is called partial fraction decomposition, and it is used to simplify complex expressions for integration, solving equations, or analysis.Partial fraction decomposition...


