"正常な"冠動脈を持つ胸痛:哲学が変化する
Raffaele Bugiardini1, C Noel Bairey Merz
1Department of Internal Medicine, Cardio-Angiology and Hepatology, University of Bologna, Bologna, Italy. raffaele.bugiardini@unibo.it
JAMA
|January 27, 2005
まとめ
胸痛と正常な冠動脈を持つ女性は,しばしば深刻な状態です. 彼らの予後は良性ではなく,さらなる心疾患リスク評価と標的治療が不可欠です.
科学分野:
- 心臓病学 心臓病学
- 血管医学 血管医学とは
背景:
- 胸痛を持つ多くの女性は,正常な冠動脈にもかかわらず,重大な心臓病がないと診断されます.
- 安心感は,しばしば提供される唯一の治療法であり,必要な介入を遅らせる可能性があります.
研究 の 目的:
- 正常または非阻害性冠動脈を持つ患者のアンギナに対する診断と治療の見直しをすること.
- この患者グループの予後と治療戦略が過小評価されていることを強調するためです.
主な方法:
- 2004年6月までのMEDLINEとコクラン体系的レビューデータベースの体系的な文献検索.
- 包括的なデータのための参照リストと会議プレゼンテーションの含有.
- キーワードは,アンギナ診断と正常血管図による治療に焦点を当てました.
主要な成果:
- 正常または非阻害性冠動脈疾患は一般的であり,特に心筋梗塞を患った女性では一般的です.
- 非阻害性疾患の患者は,女性や非白人であり,阻害性疾患と区別できない症状を持つ可能性が高い.
- 正常な血管検査を受けた女性の有意な割合は,内皮機能不全による心筋不全を示し,将来の心臓発作のリスクが増加することを示しています.
結論:
- 正常な血管図による胸痛は,主に女性に影響し,しばしば想定されるよりもより深刻な予後を伴う.
- 内皮機能の評価は,将来の心臓イベントのリスクのある患者を特定することができます.
- 治療には,症状緩和 (トリサイクル剤,ベータブロッカー) と,リスク要因に基づいて積極的な抗動脈硬化治療 (スタチン,ACE阻害剤) が含まれるべきです.
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