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Updated: May 13, 2026

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

ハプロインサフィエンス腫瘍抑制剤p18は,ATM/ATRとの相互作用によりp53を上調する

Bum-Joon Park1, Jin Wook Kang, Sang Won Lee

  • 1National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.

Cell
|February 1, 2005
PubMed
まとめ

この研究は,p18がDNA損傷反応に不可欠であり,腫瘍抑制剤として作用することを明らかにしています. その欠如は,胚の死亡率と腫瘍の感受性の増加につながり,ATM/ATRとp53.3を活性化する役割を強調します.

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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence04:56

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