西洋の女性における通常の食事による植物エストロゲン摂取量と心血管疾患リスクに関する前向きな研究
Yvonne T van der Schouw1, Sanne Kreijkamp-Kaspers, Petra H M Peeters
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room STR 6.131, PO Box 85500, 3508 GA Utrecht, Netherlands. y.t.vanderschouw@umcutrecht.nl
Circulation
|February 3, 2005
まとめ
通常の低フィトエストロゲン摂取は,女性の心血管疾患リスクを低下させなかった. しかし,リグナンの摂取量が高いと,特に喫煙者の場合,冠動脈疾患のリスクが潜在的に低下することが示されました.
科学分野:
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
- 心血管伝染病学 心血管伝染病学
- ダイエット用フィトエストロゲン
背景:
- フィトエストロゲンは,潜在的に心血管疾患に有益な植物化合物です.
- 以前の研究は,高い摂取量とリスク要因に焦点を当て,病気を明らかにしなかった.
- この研究では,通常の低フィトエストロゲン摂取量と心血管疾患 (CVD) のリスクを調査しました.
研究 の 目的:
- 習慣的な低フィトエストロゲン摂取量と心血管疾患のリスクを明らかにするとの関連を調査する.
- 食事中のイソフラボンとリグナンが一般集団におけるCVDリスクに影響するかどうかを判断する.
主な方法:
- オランダのProspect-EPICコホートから16,165人の女性 (49-70歳) が75ヶ月間追跡調査されました.
- フィトエストロゲン摂取量 (イソフラボン,リグナン) は,食事頻度アンケートを使用して評価されました.
- 複数のリスク因子と混同因子に調整されたコックス回帰分析を使用した.
主要な成果:
- イソフラボンもリグナンも,心血管疾患 (冠動脈性心疾患 (CHD) または脳血管疾患 (CVD)) のリスクの全体的な低下と関連していません.
- 喫煙歴のある女性では,リグナンの摂取量を増やすことで,心血管疾患のリスクが低下することが観察されました.
結論:
- 低用量のフィトエストロゲンの摂取は,一般人では心臓血管疾患から保護しないようです.
- リグナンの消費量が高い喫煙者にとって,冠動脈性心疾患の潜在的リスク低下が存在する.
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