生化学:ピロロキノリンキノンはビタミンですか?
Robert Rucker1, David Storms, Annemarie Sheets
1Department of Nutrition, College of Agriculture and Environmental Sciences, University of California, Davis, California 95616, USA. rbrucker@ucdavis.edu
Nature
|February 4, 2005
まとめ
ピロロキノリンキノン (PQQ) は新しいビタミンとして提案されました. しかし,この研究では,歯類におけるリジン代謝指標に対するPQQ欠乏の効果は認められず,そのビタミン状態が疑問視された.
科学分野:
- バイオケミストリー バイオケミストリー
- 栄養科学とは,栄養科学である.
- メタボリック研究
背景:
- カサハラとカトは,ピロロキノリンキノン (PQQ) を新しいビタミンとして提案した.
- 彼らの結論は,PQQ欠乏した歯類におけるリジン代謝の観察された欠陥に基づいていた.
研究 の 目的:
- PQQ欠乏症とライシン代謝の欠陥を結びつける発見を再現する.
- PQQ.の提案されたビタミン状態を批判的に評価する.
主な方法:
- 肝臓におけるアルファ-アミノアディピック酸-デルタ-セミアルデヒド (AAS) デヒドロゲンゼの活性評価.
- アルファ-アミノアディピク酸 (AAA) の血濃度を測定する.
- これらの指標をPQQ補給されたネズミとPQQ欠乏したネズミで比較する.
主要な成果:
- 肝臓のAASデヒドロゲネーゼ活性において,有意な変化は見られなかった.
- 血AAAレベルは,食事によるPQQ状態の影響を受けませんでした.
- これらの発見は,ライシン代謝障害の初期主張と矛盾しています.
結論:
- この研究の結果は,PQQを必須ビタミンとして特定することを支持していません.
- 哺乳類のリジン代謝におけるPQQの提案された役割については,さらなる調査が必要である.
- PQQをビタミンとして分類することは,現在の証拠に基づいて疑わしい.
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