低血アディポネクチンのレベルは,冠動脈カルシフィケーションの進行を予測します
David M Maahs1, Lorraine G Ogden, Gregory L Kinney
1Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA. David.Maahs@uchsc.edu
Circulation
|February 9, 2005
まとめ
低レベルのアディポネクチンは,1型糖尿病と非糖尿病の両方において冠動脈カルシフィケーションの進行を予測します. この関連性は,他の心血管疾患の危険因子とは無関係であり,アディポネクトニンを強調しています.
科学分野:
- 心血管医学 心血管医学
- エンドクリノロジー エンドクリノロジー
- メタボリックシンドロームとは
背景:
- 循環中のアディポネクチンは,男性,進行冠動脈疾患,肥満,および2型糖尿病において低い.
- リスク因子とは無関係な動脈硬化症の発症における低アディポネクチンの予測的役割は不明である.
研究 の 目的:
- 低レベルのアディポネクチンが冠動脈カルシフィケーション (CAC) の進行を予測するかどうかを調査する.
- 1型糖尿病患者および非糖尿病患者におけるこの関連性を評価する.
主な方法:
- ネストされた症例対照研究では,CACの進行が顕著な101例と205例の対照群の血アディポネクチンのレベルを分析した.
- ベースラインのCAC量およびその他の予測要因に調整された条件付きロジスティック回帰モデル.
- 分析には,タイプ1糖尿病と非糖尿病の19~59歳の参加者が含まれていました.
主要な成果:
- アディポネクチンの濃度は,糖尿病 (OR,0.47) と非糖尿病 (OR,0.15) の両方の被験者において,CACの進行と逆に関連していた.
- この関連性は,追加の心血管疾患の危険因子を調整した後も維持された.
- すべての参加者 (P<0.001) で,アディポネクチン四分位数のCAC進行の統計的に有意な傾向が観察されました.
結論:
- 低血アディポネクチンのレベルは,1型糖尿病患者および非糖尿病患者のCAC進行と関連しています.
- この関連性は,他の心血管疾患の危険因子とは独立しています.
- アディポネクチンは,動脈硬化症の進行の独立した予測剤として機能する可能性があります.
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