急性心筋梗塞の患者の30日間の死亡率において,断食中のグルコースは重要な独立リスク因子である:前向きな研究
Mahmoud Suleiman1, Haim Hammerman, Monther Boulos
1Department of Cardiology, Rambam Medical Center, and the Bruce Rappaport Faculty of Medicine, Haifa, Israel.
Circulation
|February 9, 2005
まとめ
入院時のグルコース (AG) ではなく,断食グルコース (FG) レベルは,急性心筋梗塞の非糖尿病患者の30日間の死亡率の有意な予測因子です. 高度のFGは,高度のAGよりも,死亡リスクの増加とより強い関連性を示しています.
科学分野:
- 心臓病学 心臓病学
- エンドクリノロジー エンドクリノロジー
- クリニック・リサーチ 臨床研究
背景:
- ストレス性高血糖症は,急性心筋梗塞 (AMI) 患者におけるより高い死亡率と関連しています.
- 以前の研究は,摂取グルコース (AG) に焦点を当て,断食グルコース (FG) のデータは限られていた.
研究 の 目的:
- 非糖尿病性AMI患者における断食グルコース (FG) と30日間の死亡率との関係を調査する.
- 短期死亡率に関するFGとAGの予測力を比較する.
主な方法:
- 735人の非糖尿病性AMI患者を対象とした前向きな研究.
- 入院後24時間以内に,断食グルコース (FG) と入院グルコース (AG) の測定.
- FGとAGレベルの異なるテルティールにおける30日間の死亡率の分析.
主要な成果:
- FG濃度の上昇と30日間の死亡率の増加との間には,段階的な関係が見られた.
- FGのより高い三位数では,死亡率に対する調整されたオッズ比 (OR) が漸進的に高くなっていた.
- 高度のAGも死亡率を予測する一方で,FGは,特にAGと組み合わせると,優れた予測価値を示しました.
結論:
- 増加した断食グルコース (FG) は,急性心筋梗塞の非糖尿病患者の30日間の死亡率の有意な独立した予測因子です.
- 断食グルコース (FG) は,この患者集団における短期死亡リスクの評価において,入院グルコース (AG) よりも効果的です.
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