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Updated: May 5, 2026

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Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis
Published on: June 15, 2011
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悪性腫瘍,前血栓変異,静脈血栓症のリスク
Jeanet W Blom1, Carine J M Doggen, Susanne Osanto
1Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
JAMA
|February 11, 2005
まとめ
がん患者は,特に診断後数ヶ月以内に,または遠隔転移で,静脈血栓症のリスクが著しく高くなります. Factor V Leidenのような遺伝子変異は,このリスクをさらに高めます.
科学分野:
- 腫瘍学 腫瘍学
- 血液学 ヘマトロジ
- 遺伝学 遺伝学とは
背景:
- 静脈血栓症は,がん患者にとって頻繁かつ深刻な合併症であり,生活の質に影響を及ぼします.
- 血栓形成のリスクが高いがん患者を特定することは,積極的な管理に不可欠です.
研究 の 目的:
- がん患者の血栓形成リスクを評価する.
- このリスクに対する腫瘍部位,転移,前血栓変異の影響を評価する.
主な方法:
- 静脈血栓症患者3220人と対照患者2131人を対象としたケース・コントロール研究 (MEGA).
- ファクターVライデンとプロトロンビン20210A変異のアンケートとDNA分析によって収集されたデータ.
主要な成果:
- がん患者は静脈血栓症のリスクが7倍に増加しました.
- 血液,肺,胃腸がんは,最も高いリスクをもたらしました.
- リスクは,診断後の最初の数ヶ月,遠隔転移,およびファクターVレイデンまたはプロトロンビン20210A変異のキャリアにおいて大幅に高かった.
結論:
- がん患者,特に最近診断された患者,または転移した患者には,静脈血栓症のリスクが著しく高まります.
- プロトロンボ性遺伝子変異は,このリスクを増幅し,個別化されたリスク評価の必要性を強調します.
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