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Updated: Jul 26, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

ヨーロッパにおける野外的抗生物質使用と耐性との関連: 国境を越えたデータベース研究

Herman Goossens1, Matus Ferech, Robert Vander Stichele

  • 1ESAC Management Team, Department of Microbiology, University of Antwerp, B-2610 Antwerp, Belgium. Herman.Goossens@uza.be

Lancet (London, England)
|February 15, 2005
PubMed
まとめ

抗生物質耐性は,公衆衛生上の懸念が高まっています. この研究では,抗生物質の消費が大きい欧州諸国において抗生物質耐性が高かったことが判明し,使用を減らすための公衆衛生戦略の必要性を強調した.

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Antibiotic Selection00:57

Antibiotic Selection

Overview
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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Clinical Significance of Antibiotic Resistance

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