甲状腺機能障害症とアルドステロン症のカルシウムパラドックス
Vikram S Chhokar1, Yao Sun, Syamal K Bhattacharya
1Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Circulation
|February 16, 2005
まとめ
アルドステロニズムは過剰なカルシウムとマグネシウムの損失を引き起こし,骨の損失と二次性副甲状腺症を引き起こします. このミネラル不均衡は,心不全における酸化ストレスと炎症に寄与する.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 心血管生理学 心血管の生理学
- ミネラルメタボリズム
背景:
- アルドステロニズムは,酸化ストレス,炎症,心不全における消耗と関連しています.
- この研究は,アルドステロン過剰がミネラルバランスと骨の健康に及ぼす全身的影響を調査しています.
研究 の 目的:
- ネズミのアルドステロン/1%NaCl治療 (ALDOST) がCa2+とMg2+の分泌を増加させるかどうかを判断する.
- 骨の損失と細胞の変化を含む,この強化された排泄の全身的影響を調査する.
主な方法:
- ネズミは,アルドステロン抗体であるALDOSTまたはスピロノラクトン (Spiro) で治療されました.
- 測定対象は,ミネラル排出量,プラズマミネラル濃度,副甲状腺ホルモン,骨密度,細胞Ca2+/Mg2+含有量などでした.
主要な成果:
- ALDOSTは,尿および便のCa2+およびMg2+排出を著しく増加させ,プラズマのイオン化されたCa2+およびMg2+レベルを低下させました.
- 骨のミネラル密度と強度が低下し,PBMCと心臓組織はCa2+過負荷を示した.
- スピロノラクトン治療は,これらの有害な効果を逆転させました.
結論:
- アルドステロニズムによって引き起こされるCa2+とMg2+の損失は,二次性パラチロイド症と骨再吸収を引き起こす.
- 細胞のCa2+過負荷は,アルドステロニズムにおける酸化ストレスと炎症に寄与する.
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