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Updated: Jul 16, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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N-アシルアリルスルフィナミドのサブチリシン触媒による解像度

Christopher K Savile1, Vladimir P Magloire, Romas J Kazlauskas

  • 1Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec, H3A 2K6, Canada.

Journal of the American Chemical Society
|February 17, 2005
PubMed
まとめ

この研究は,非対称なアミン合成に不可欠なキラルスルフィナミドを生成するための最初のバイオカタリティック方法を導入しています. 特定の酵素であるサブチリシンEは,これらの化合物を分解する際に高いエナチオセレクティブ性を示し,貴重なキラル補助物質を生成しました.

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