皮膚性メラノーマは皮膚性メラノーマである
John F Thompson1, Richard A Scolyer, Richard F Kefford
1Sydney Melanoma Unit, University of Sydney at Royal Prince Alfred Hospital, Sydney, Camperdown, New South Wales, Australia. thompson@smu.org.au
Lancet (London, England)
|February 22, 2005
まとめ
強烈な日光曝露はメラノーマのリスクを高めます. 手術による切除は早期診断の鍵ですが,新しい分子標的は進行性メラノーマの治療に有望です.
科学分野:
- 皮膚病学と腫瘍学について
- 遺伝学と分子生物学について
背景:
- メラノーマの発生率は,強烈な日光曝露に関連して,世界的に増加しています.
- CDKN2AおよびCDK4遺伝子の遺伝性突然変異は,メラノーマの感受性を著しく増加させる.
- 早期診断と手術による切除は,効果的なメラノーマ治療に不可欠です.
研究 の 目的:
- メラノーマに関する現在の理解と治療戦略をレビューする.
- メラノーマ管理のための新興の診断および治療アプローチを強調する.
主な方法:
- メラノーマの発生率,遺伝,診断,治療に関する既存の文献のレビュー.
- センチネルリンパ節生検や磁気共鳴光譜検査などの診断技術についての議論.
- 補助療法および標的分子治療のための進行中の臨床試験の概要.
主要な成果:
- センチネルリンパ節生検はステージを決定するのに役立ちますが,地域結節解剖の治療効果にはさらなる臨床試験データが必要です.
- 非侵襲的なセンチネルノード評価のために,磁気共鳴スペクトロスコーピーは調査されています.
- 現在の補助療法では,メラノーマ患者の全生存期間を決定的に改善するものはない.
結論:
- 外科的切除は,局所性メラノーマの主要な治療法であり続けています.
- 分子経路を調査する標的型療法が,転移性メラノーマの管理に将来の可能性を秘めている.
- ワクチン,サイトカイン,分子標的に関する継続的な研究は,メラノーマ治療の進歩に不可欠です.
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