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標的型タンパク質分解は,カルシヌーリンの活性化を維持する

Natalie Burkard1, Jan Becher, Cornelia Heindl

  • 1Department of Medicine, University of Wuerzburg, Wuerzburg, Germany.

Circulation
|February 23, 2005
PubMed
まとめ

アンジオテンシンIIによるカルパインの活性化は,カルシヌーリンの自己抑制ドメインのタンパク質分解を誘発し,カルシヌーリンの活性と心臓筋細胞における核転移を増加させます. このメカニズムは,病理的な心筋縮症に寄与する.

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