関連する実験動画

Updated: Jul 9, 2026

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
10:05

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

Published on: August 13, 2012

CFTRチャネルは,そのヌクレオチド結合ドメインのATP駆動の緊密な二分化によって開きます

Paola Vergani1, Steve W Lockless, Angus C Nairn

  • 1Laboratory of Cardiac/Membrane Physiology, The Rockefeller University, New York, New York 10021, USA. paola.vergani@rockefeller.edu

Nature
|February 25, 2005
PubMed
まとめ

性線維症のトランスメブラン伝導性調節器 (CFTR) のイオンチャネルは,その нуклеотиド結合ドメインがATPによって駆動され,緊密に二酸化すると開きます. この二重化プロセスは,ABCタンパク質のイオン輸送の調節に極めて重要です.

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Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time08:33

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time

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