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Updated: Jul 14, 2026

08:38
Oral Transmission of Listeria monocytogenes in Mice via Ingestion of Contaminated Food
Published on: May 6, 2013
霊長類における牛のスポンジ状脳病原体による口腔感染症のリスク
Corinne Ida Lasmézas1, Emmanuel Comoy, Stephen Hawkins
1Commissariat à l'Energie Atomique/Direction des Sciences du Vivant/Départment de Recherche Médicale, 18 Route du Panorama, 92265 Fontenay-aux-Roses, France.
Lancet (London, England)
|March 1, 2005
まとめ
この研究では,牛のスポンジ状脳症 (BSE) がヒト以外の霊長類に経口感染することを調査しました. 1匹のマカクは,クルーツフェルト・ヤコブ病 (vCJD) に似た疾患の変種を発症し,ヒトの暴露に対するリスク評価に情報を提供した.
科学分野:
- 神経科学は神経科学である.
- プリオン病の研究
- 感染症疫学 感染症疫学
背景:
- 牛のスポンジ状脳症 (BSE) に人間の曝露は,変異型クレッツフェルト・ヤコブ病 (vCJD) のリスクを伴う.
- 経口プリオン伝達と牛から人間へのバリアの効率は,まだ完全に理解されていません.
- これらの要因を評価することは,公衆衛生上のリスク管理において極めて重要です.
研究 の 目的:
- ヒト以外の霊長類へのBSEの経口感染を調査する.
- プリオン病の牛から人間への感染の可能性を評価する.
- 食事によるBSEへの曝露に関するリスク評価に情報を提供するためです.
主な方法:
- 2匹のマカクは,BSEに感染した牛の脳ホモゲネート5gの口服投与を受けた.
- 被験者はvCJDのような神経疾患の発症をモニタリングした.
- インキュベーション期間と疾患の進行を観察した.
主要な成果:
- あるマカクは,暴露後60ヶ月でvCJDのような神経疾患を発症した.
- 2番目のマカクは,暴露後76ヶ月で病気から自由でした.
- 発見は,口腔でのBSE伝播の可能性を示唆していますが,それは変動します.
結論:
- 霊長類への経口のBSE感染は可能であり,インキュベーション期間が長い.
- 結果は,ヒトへの感染を防ぐために現在の公衆衛生対策の有効性を支持しています.
- さらなる研究により,BSEによるヒトの食品被曝リスクの推定値を精査することができます.
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