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Updated: Jul 27, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

単細胞におけるインタールイキン-1βの処理には,新しい異体サイステインプロテアスが必要である

N A Thornberry1, H G Bull, J R Calaycay

  • 1Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065.

Nature
|April 30, 1992
PubMed
まとめ

研究者は,インタールイキン-1β (IL-1β) 変換酵素,システインプロテアゼ,および設計された阻害剤を特定しました. モノサイトにおけるこの酵素を阻害すると,成熟したIL-1βの産生が停止し,炎症の治療標的として示唆される.

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Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells09:43

Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells

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