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Updated: Jun 24, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

HLA-DR分子ベータ2ドメインのCD4結合部位を特定

G Cammarota1, A Scheirle, B Takacs

  • 1International Institute of Genetics and Biophysics, Italy.

Nature
|April 30, 1992
PubMed
まとめ

この研究は,CD4がMHCクラスIIの分子と相互作用することを示しており,CD8がMHCクラスIと結合する方法と類似しています. この発見は,T細胞受容体と抗原を提示する細胞の間の分子相互作用を明確にします.

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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...