タバコを吸う母親の胎児のアンニオサイトにおける染色体不安定性

Rosa Ana de la Chica¹, Isabel Ribas, Jesús Giraldo

¹Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.

JAMA

|March 10, 2005

まとめ

母親の喫煙は胎児細胞の染色体不安定性を高め,特に帯11q23が影響を受ける. これは,妊娠中の喫煙による遺伝子毒性効果を示唆している.

科学分野:

遺伝学遺伝学とは
毒理学毒理学毒理学
産科は産婦人科です.

背景:

タバコの使用は,全身の健康と妊娠の結果にリスクをもたらします.
喫煙がヒトの妊娠に与える直接的な遺伝子毒性影響に関するデータは限られている.

研究の目的:

母親の喫煙が胎児細胞に与える遺伝子毒性の影響を調査する.
喫煙が胎児細胞の染色体不安定性を高めるかどうかを評価する.
タバコの曝露に脆弱な特定の染色体領域を特定する.

主な方法:

25人の喫煙母と25人のアンニオセントーシスを受けた対照群を対象とした前向きな研究.
染色体の病変や異常を検出するためにアンニオサイトの採取と細胞遺伝分析を行う.
影響を受けた染色体領域のブレイクポイントを特定するために使用されるG-バンド.

主要な成果:

喫煙者の羊膜細胞における構造的な染色体異常の比率はかなり高かった (12.1%対3.5%).
染色体不安定性の増加と,喫煙する母親の胎児細胞で観察された病変.
バンド11q23は,最も影響を受けた染色体領域として特定されました.

結論:

妊婦が妊娠中に10年以上1日10本以上のタバコを吸うことは,乳腺細胞の染色体不安定性の上昇と関連している.
バンド11q23は,白血病発生と関連しており,タバコの遺伝子毒性化合物に対する感受性の高まりを示しています.

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