人間の共生生物は,表面のフクソシル化のために宿主のような経路を使用します

Michael J Coyne¹, Barbara Reinap, Martin M Lee

¹Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)

|March 19, 2005

まとめ

バクテロイド菌はL-フコースで表面を飾り,腸内の宿主細胞を模倣する. このL-フコースの装飾は,哺乳類の腸を成功裏に植民地化するために不可欠です.

科学分野:

微生物学微生物学とは
ホストと微生物の相互作用
グライコバイオロジーは,

背景:

哺乳類の腸は,密集した共生的な微生物群を宿している.
ホストの免疫システムは,共生細菌を許容し,病原体を排除します.
宿主-微生物共生の分子メカニズムを理解することは極めて重要です.

研究の目的:

バクテロイドの腸内植民における表面分子装飾の役割を調査する.
バクテロイドがコロニー化のために宿主由来分子を利用するかどうかを判断する.
宿主-微生物の相互作用におけるL-フクゾーズの機能を明らかにする.

主な方法:

バクテロイドの表面カプセルポリサッカリドおよびグリコタンパク質の分析.
バクテロイドの遺伝子操作により,L-フコゼ欠乏変異体が生成される.
哺乳類の腸モデルにおける競争的植民地化アッセイ.

主要な成果:

バクテロイドは,表面ポリサッカライドとグリコタンパク質をL-フクゾーで飾ります.
この装飾は,腸内上皮細胞のL-フコース発現を模倣しています.
L-フコゼの表面装飾が欠けている突然変異体は,腸内コロニゼーションの障害を示した.

結論:

バクテロイドは,L-フコースの装飾のための哺乳類のような経路を採用しています.
バクテロイドによるL-フクゾーズの表面発現は,競争的なコロニー化に不可欠である.
この研究は,腸内における宿主-共生体の分子模倣のメカニズムを明らかにしています.

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