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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
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hDM2に対するβ-ペプチドリガンドの溶液構造

Joshua A Kritzer1, Michael E Hodsdon, Alanna Schepartz

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06510, USA.

Journal of the American Chemical Society
|March 24, 2005
PubMed
まとめ

beta53-1のようなβ-ペプチドの折り畳み体は,タンパク質の相互作用を抑制するためにアルファヘリクスを模倣する. そのユニークな構造は,タンパク質インターフェイスをターゲットにするための新しい折り畳みと認識要素を明らかにします.

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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