アラビドプシスのゲノム外情報に関する全ゲノムにわたるメンデルの非遺伝
Susan J Lolle1, Jennifer L Victor, Jessica M Young
1Department of Botany and Plant Pathology, Purdue University, 915 W. State Street, West Lafayette, Indiana 47907-2054, USA.
Nature
|March 24, 2005
まとめ
古典的な遺伝学では,安定した遺伝を前提としているが,アラビドプシスの植物では,アレル特異のDNA修復が示されている. このエキストラゲノム遺伝メカニズムは,祖先のRNA配列を用いて,既定の遺伝的原理に挑戦しています.
科学分野:
- 遺伝学 遺伝学とは
- 分子生物学は分子生物学である.
- 植物科学 植物科学について
背景:
- 古典的なメンデルの遺伝学は,世代を超えてアレルの安定した,予測可能な遺伝を仮定しています.
- 安定的な遺伝に対する既知の例外は,特定の遺伝子またはアレルタイプに機械的に制限されています.
研究 の 目的:
- アラビドプシスのアレル固有のDNA配列遺伝の新しいメカニズムを調査する.
- 両親に欠けていた遺伝情報を,以前の世代から復元できるかどうかを判断する.
主な方法:
- 利用されたアラビドプシスは,HOTHEAD (HTH) 遺伝子のリセシブ変異アレルに同同同位体を持つ植物である.
- 遺伝的,非親の遺伝情報の例を特定するためにDNA配列のポリモルフィズムを調べた.
主要な成果:
- 親の染色体ゲノムに存在しない子孫におけるアレル固有のDNA配列情報を観察した.
- この遺伝は,検査されたすべてのDNA配列ポリモルフィズムで発生し,一般的なメカニズムを示唆していることが示されました.
- この現象に関与しているHOTHEAD (HTH) 遺伝子を特定しました.
結論:
- DNA配列情報の遺伝子外継承という,これまで説明されていないプロセスが存在します.
- この遺伝子修復には,祖先のRNA配列キャッシュを利用したテンプレート主導のメカニズムが関与している可能性が高い.
- 安定したアレル遺伝に関するメンデルの遺伝学の基本原理に異議を唱える.
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