ファンギウリアの治療法
A Wong-Beringer1, R A Jacobs, B J Guglielmo
1Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0622.
JAMA
|May 27, 1992
まとめ
抗真菌膀灌,特にアンフォテリシンBは,合併症のない真菌症の治療に有望である. しかし,一貫性のない研究設計は,真菌性尿路感染症の最終的な治療推奨を制限しています.
科学分野:
- 菌類学 菌類学とは
- 感染症 感染症は感染症です.
- 薬理学 薬理学とは
背景:
- 尿中の真菌菌,または真菌の存在は,特に医療環境では,ますます懸念される問題です.
- 合併症のない真菌症は,質の高い証拠が限られているため,明確な治療ガイドラインが欠けている.
研究 の 目的:
- 合併症のない真菌病に対する抗真菌治療の検討と評価を行う.
- 効果的な抗真菌剤を特定し,治療結果に対するリスク因子の影響を評価する.
主な方法:
- 合併症のない真菌症の治療に関する英語の症例報告と研究 (1960-1991) の体系的なレビュー.
- 試験設計,定義,治療レジメン,リスク要因,患者のフォローアップの分析.
主要な成果:
- 抗真菌薬の直接比較は,研究方法の異質性によって妨げられた.
- アンフォテリシンBの膀灌が最も効果的であり,ケトコナゾールは最も効果的ではない.
- 尿路カテーテルなどの予備性要因は,治療失敗に大きく影響します.
結論:
- 現在の証拠は,合併症のない真菌病の特定の治療法を推奨するのに不十分です.
- 最適な治療戦略を確立するために,前向きでよくコントロールされた研究が必要である.
- 症状のある症例は治療が必要ですが,最良のアプローチは未定です.
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