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Updated: Aug 7, 2026

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
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p56lckckが欠けているマウスのチモサイト発育に深刻な阻害がある

T J Molina1, K Kishihara, D P Siderovski

  • 1Ontario Cancer Institute, University of Toronto, Canada.

Nature
|May 14, 1992
PubMed
まとめ

T細胞特異的なチロシンキナーゼであるLck (p56lck) タンパク質は,T細胞の発達に不可欠である. Lck欠乏症のマウスは,チモサイト成熟と周辺T細胞集団の深刻な欠陥を示し,その重要な役割を強調しています.

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Inhibition of Cdk Activity02:34

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...