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Updated: Jun 23, 2026

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 22, 2012

セレコキシブは,c-Jun端末NH2キナーゼのリン酸化を阻害することにより,内皮組織因子発現を低下させます

Jan Steffel1, Matthias Hermann, Helen Greutert

  • 1Cardiovascular Research, Physiology Institute, University of Zurich, Switzerland.

Circulation
|March 30, 2005
PubMed
まとめ

セレコキシブは,他のコキシブとは異なり,ヒト大動脈細胞における組織因子 (TF) 発現を,JNK.を阻害することによって減少させます. これは,心血管疾患の患者にとって重要な明確な薬物効果を示唆しています.

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