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Marietta Charakida1, Ann E Donald, Mari Terese

  • 1Vascular Physiology Unit, 30 Guilford St, London WC1N 1EH, United Kingdom. charakidadoc@hotmail.com.

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|March 30, 2005
PubMed
まとめ

幼児期の急性感染症は,動脈硬化症の重要な初期段階である血管機能を損なう. これは,感染が幼い頃からこの状態の発達に役割を果たす可能性があることを示唆しています.

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科学分野:

  • 小児の健康に関する小児保健
  • 心血管研究 循環器科の研究
  • 免疫学 免疫学とは

背景:

  • 動脈硬化症は幼少期に始まり,重要な初期イベントとして内皮機能不全があります.
  • 幼児期の急性感染症が血管内皮に及ぼす影響は,依然としてほとんど不明である.

研究 の 目的:

  • 幼児期の急性感染症が内皮機能に与える影響を調査する.
  • 感染症が動脈硬化症に関連した早期の血管変化に寄与するかどうかを判断する.

主な方法:

  • 10歳児600人の子どもを対象に,親と子供のエイヴォン・ロングティチューディナル研究を行いました.
  • 高解像度超音波による腕動脈流媒介拡張 (FMD) を使用して内皮機能の評価.
  • 急性感染,最近の感染 (回復期) と健康な対照群の子供における口腔炎の比較.

主要な成果:

  • 急性感染症 (AI) を患った子どもと回復期児は,健康な対照群と比較して,著しく低い口腔炎を発症した (P<0.001).
  • これらの差異は,混同要因を調整した後も持続しました.
  • 急性感染症の子どもでは,口腔炎は1年後に著しく改善したが,対照群は変化しなかった.

結論:

  • 幼児期の急性感染症は,内皮に依存した血管拡張の障害と関連しています.
  • 研究結果は,感染症などの外的な炎症的刺激が,早期の動脈硬化症の病原化に寄与する可能性があることを示唆しています.