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Updated: Jul 19, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

PDK1は,NF-kappaBの活性化のためのT細胞受容体誘発信号複合体であるPDK1を核化する

Ki-Young Lee1, Fulvio D'Acquisto, Matthew S Hayden

  • 1Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA.

Science (New York, N.Y.)
|April 2, 2005
PubMed
まとめ

3フォスホイノシチド依存キナーゼ1 (PDK1) は,T細胞受容体 (TCR) をNF-kappaB信号伝達にリンクすることにより,T細胞活性化に不可欠です. PDK1は,タンパク質キナーゼC (PKC) とCARD11募集を調節し,T細胞の増殖と適応免疫を開始します.

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